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1

How to Achieve Confidence in Drug Discovery and Development: Managing Risk (from a Reductionist to a Holistic Approach)

Annette Bakker, Andrea Caricasole, Giovanni Gaviraghi, Giuseppe Pollio, Graeme Robertson, Georg C. Terstappen, Massimiliano Salerno, Patrizia Tunici

Journal:

Year:

2009

Language:

english

File:

PDF, 1012 KB

english, 2009

2

Rapid aggregation and assembly in aqueous solution of Aβ(25–35) peptide

Lia Millucci, Roberto Raggiaschi, Davide Franceschini, Georg Terstappen, Annalisa Santucci

Journal:

Journal of Biosciences

Year:

2009

Language:

english

File:

PDF, 964 KB

english, 2009

3

Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLCβ1)

Andrea Caricasole, Cinzia Sala, Renza Roncarati, Elisa Formenti, Georg C. Terstappen

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

2000

Language:

english

File:

PDF, 1.33 MB

english, 2000

4

Targeting the p53 tumor suppressor gene function in glioblastomas using small chemical molecules

Roberta Magrini, Annette Bakker, Giovanni Gaviraghi, Georg C. Terstappen

Journal:

Drug Development Research

Year:

2006

Language:

english

File:

PDF, 162 KB

english, 2006

5

Isolation of Gangliosides by Cloud-Point Extraction with a Nonionic Detergent

Andreas Schwarz, Georg C. Terstappen, Anthony H. Futerman

Journal:

Analytical Biochemistry

Year:

1997

Language:

english

File:

PDF, 144 KB

english, 1997

6

Functional Analysis of Native and Recombinant Ion Channels Using a High-Capacity Nonradioactive Rubidium Efflux Assay

Georg C. Terstappen

Journal:

Analytical Biochemistry

Year:

1999

Language:

english

File:

PDF, 134 KB

english, 1999

7

Aryl azoles with neuroprotective activity—Parallel synthesis and attempts at target identification

Giuseppe Cocconcelli, Enrica Diodato, Andrea Caricasole, Giovanni Gaviraghi, Eva Genesio, Chiara Ghiron, Letizia Magnoni, Elena Pecchioli, Pier Vincenzo Plazzi, Georg C. Terstappen

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 277 KB

english, 2008

8

Solid-phase/solution-phase combinatorial synthesis of neuroimmunophilin ligands

Michael Rabinowitz, Pierfausto Seneci, Tino Rossi, Michele Dal Cin, Martyn Deal, Georg Terstappen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 143 KB

english, 2000

9

Detection of phosphorylation patterns in rat cortical neurons by combining phosphatase treatment and DIGE technology

Roberto Raggiaschi, Chiara Lorenzetto, Enrica Diodato, Andrea Caricasole, Stefano Gotta, Georg C. Terstappen

Journal:

Year:

2006

Language:

english

File:

PDF, 2.92 MB

english, 2006

10

Sequential detergent fractionation of primary neurons for proteomics studies

Simonetta Bernocco, Costanza Fondelli, Silvia Matteoni, Letizia Magnoni, Stefano Gotta, Georg C. Terstappen, Roberto Raggiaschi

Journal:

Year:

2008

Language:

english

File:

PDF, 503 KB

english, 2008

11

Molecular cloning of abscisic acid-modulated genes which are induced during desiccation of the resurrection plantCraterostigma plantagineum

Dorothea Bartels, Katharina Schneider, Georg Terstappen, Detlef Piatkowski, Francesco Salamini

Journal:

Year:

1990

Language:

english

File:

PDF, 2.09 MB

english, 1990

12

Phosphoproteome Analysis

Roberto Raggiaschi, Stefano Gotta, Georg C. Terstappen

Journal:

Bioscience Reports

Year:

2005

Language:

english

File:

PDF, 322 KB

english, 2005

13

Editorial Note

Roberto Raggiaschi, Georg C. Terstappen

Journal:

Bioscience Reports

Year:

2005

Language:

english

File:

PDF, 152 KB

english, 2005

14

Editorial Note

Georg C. Terstappen

Journal:

Bioscience Reports

Year:

2005

Language:

english

File:

PDF, 117 KB

english, 2005

15

A Bioinformatics Perspective on Proteomics: Data Storage, Analysis, and Integration

Andreas Kremer, Reinhard Schneider, Georg C. Terstappen

Journal:

Bioscience Reports

Year:

2005

Language:

english

File:

PDF, 236 KB

english, 2005

16

Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells

Alessandra Caruso, Marta Motolese, Luisa Iacovelli, Filippo Caraci, Agata Copani, Ferdinando Nicoletti, Georg C. Terstappen, Giovanni Gaviraghi, Andrea Caricasole

Journal:

Journal of Neurochemistry

Year:

2006

Language:

english

File:

PDF, 261 KB

english, 2006

17

Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease

Maria Cristina Rosi, Ilaria Luccarini, Cristina Grossi, Anna Fiorentini, Maria Grazia Spillantini, Antonella Prisco, Carla Scali, Marco Gianfriddo, Andrea Caricasole, Georg C. Terstappen, Fiorella Cas

Journal:

Journal of Neurochemistry

Year:

2010

Language:

english

File:

PDF, 1.16 MB

english, 2010

18

Target deconvolution strategies in drug discovery

Schlüpen, Christina, Raggiaschi, Roberto, Gaviraghi, Giovanni, Terstappen, Georg C.

Journal:

Nature Reviews Drug Discovery

Year:

2007

Language:

english

File:

PDF, 995 KB

english, 2007

19

Functional Properties of α7 Nicotinic Acetylcholine Receptors Co-expressed with RIC-3 in a Stable Recombinant CHO-K1 Cell Line

Roncarati, Renza, Seredenina, Tamara, Jow, Brian, Jow, Flora, Papini, Silvia, Kramer, Angela, Bothmann, Hendrick, Dunlop, John, Terstappen, Georg C.

Journal:

Assay and Drug Development Technologies

Year:

2008

Language:

english

File:

PDF, 1.15 MB

english, 2008

20

In vitro screening strategies for nicotinic receptor ligands

John Dunlop, Renza Roncarati, Brian Jow, Hendrick Bothmann, Tim Lock, Dianne Kowal, Mark Bowlby, Georg C. Terstappen

Journal:

Biochemical Pharmacology

Year:

2007

Language:

english

File:

PDF, 716 KB

english, 2007

21

Small molecule drug discovery for Huntington's Disease

Wolfgang Fecke, Marco Gianfriddo, Giovanni Gaviraghi, Georg C. Terstappen, Freddy Heitz

Journal:

Drug Discovery Today

Year:

2009

Language:

english

File:

PDF, 311 KB

english, 2009

22

Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1

Carla Scali, Filippo Caraci, Marco Gianfriddo, Enrica Diodato, Renza Roncarati, Giuseppe Pollio, Giovanni Gaviraghi, Agata Copani, Ferdinando Nicoletti, Georg C. Terstappen, Andrea Caricasole

Journal:

Neurobiology of Disease

Year:

2006

Language:

english

File:

PDF, 1.56 MB

english, 2006

23

Pharmacological and molecular characterisation of SK3 channels in the TE671 human medulloblastoma cell line

Corrado Carignani, Renza Roncarati, Rebecca Rimini, Georg C. Terstappen

Journal:

Year:

2002

Language:

english

File:

PDF, 341 KB

english, 2002

24

Pharmacological properties of rat α7 nicotinic receptors expressed in native and recombinant cell systems

Caterina Virginio, Angelo Giacometti, Laura Aldegheri, Joseph M Rimland, Georg C Terstappen

Journal:

European Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 207 KB

english, 2002

25

Nitrogen substitution modifies the activity of cytisine on neuronal nicotinic receptor subtypes

Eric Carbonnelle, Fabio Sparatore, Caterina Canu-Boido, Cristian Salvagno, Barbara Baldani-Guerra, Georg Terstappen, Ruud Zwart, Henk Vijverberg, Francesco Clementi, Cecilia Gotti

Journal:

European Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 361 KB

english, 2003

26

Robust MS quantification method for phospho-peptides using18O/16O labeling

Claus A Andersen, Stefano Gotta, Letizia Magnoni, Roberto Raggiaschi, Andreas Kremer, Georg C Terstappen

Journal:

BMC Bioinformatics

Year:

2009

Language:

english

File:

PDF, 985 KB

english, 2009

27

Huntington's disease: from experimental results to interaction networks, patho-pathway construction and disease hypothesis

Eduardo Gonzalez-Couto, Silvia Matteoni, Stefano Gotta, Letizia Magnoni, Freddy Heitz, Roberto Raggiaschi, Georg C Terstappen, Andreas Kremer

Journal:

BMC Systems Biology

Year:

2007

Language:

english

File:

PDF, 317 KB

english, 2007

28

Identification, Gene Structure, and Expression of Human Frizzled-3 (FZD3)

Cinzia F. Sala, Elisa Formenti, Georg C. Terstappen, Andrea Caricasole

Journal:

Biochemical and Biophysical Research Communications

Year:

2000

Language:

english

File:

PDF, 319 KB

english, 2000

29

Differential inhibition of rat α3* and α7 nicotinic acetylcholine receptors by tetrandrine and closely related bis-benzylisoquinoline derivatives

Caterina Virginio, Francesca Graziani, Georg C. Terstappen

Journal:

Neuroscience Letters

Year:

2005

Language:

english

File:

PDF, 262 KB

english, 2005

30

Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades

Hannah K. Delille, Judith M. Becker, Sabrina Burkhardt, Barbara Bleher, Georg C. Terstappen, Martin Schmidt, Axel H. Meyer, Liliane Unger, Gerard J. Marek, Mario Mezler

Journal:

Neuropharmacology

Year:

2012

Language:

english

File:

PDF, 652 KB

english, 2012

31

In silico research in drug discovery

Georg C. Terstappen, Angelo Reggiani

Journal:

Trends in Pharmacological Sciences

Year:

2001

Language:

english

File:

PDF, 39 KB

english, 2001

32

The Wnt pathway, cell-cycle activation and β-amyloid: novel therapeutic strategies in Alzheimer's disease?

Andrea Caricasole, Agata Copani, Alessandra Caruso, Filippo Caraci, Luisa Iacovelli, Maria Angela Sortino, Georg C Terstappen, Ferdinando Nicoletti

Journal:

Trends in Pharmacological Sciences

Year:

2003

Language:

english

File:

PDF, 254 KB

english, 2003

33

Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain

Rebecca Rimini, Joseph M Rimland, Georg C Terstappen

Journal:

Molecular Brain Research

Year:

2000

Language:

english

File:

PDF, 266 KB

english, 2000

34

Lithium induces gene expression through lymphoid enhancer-binding factor/T-cell factor responsive element in rat PC12 cells

Ezio Bettini, Enrico Magnani, Georg C. Terstappen

Journal:

Neuroscience Letters

Year:

2002

Language:

english

File:

PDF, 81 KB

english, 2002

35

The antidepressant fluoxetine blocks the human small conductance calcium-activated potassium channels SK1, SK2 and SK3

Georg C. Terstappen, Annalisa Pellacani, Laura Aldegheri, Francesca Graziani, Corrado Carignani, Giordano Pula, Caterina Virginio

Journal:

Neuroscience Letters

Year:

2003

Language:

english

File:

PDF, 98 KB

english, 2003

36

Molecular cloning and initial characterization of the MG61/PORC gene, the human homologue of the Drosophila segment polarity gene Porcupine

Andrea Caricasole, Teresa Ferraro, Joseph M. Rimland, Georg C. Terstappen

Journal:

Year:

2002

Language:

english

File:

PDF, 632 KB

english, 2002

37

Nonradioactive Rubidium Ion Efflux Assay and Its Applications in Drug Discovery and Development

Terstappen, Georg C.

Journal:

Assay and Drug Development Technologies

Year:

2004

Language:

english

File:

PDF, 112 KB

english, 2004

38

P2-062: A new cellular-based approach for target validation in neurodegenerative diseases

Giuseppe Pollio, Renza Roncarati, Enrica Diodato, Andrea Caricasole, Georg C. Terstappen

Journal:

Alzheimer's & Dementia

Year:

2006

Language:

english

File:

PDF, 54 KB

english, 2006

39

Protein partitioning in detergent-based aqueous two-phase systems

Georg C. Terstappen, R.Andrew Ramelmeier, Maria-Regina Kula

Journal:

Journal of Biotechnology

Year:

1993

Language:

english

File:

PDF, 701 KB

english, 1993

40

Ion channel screening technologies today

Georg C. Terstappen

Journal:

Drug Discovery Today: Technologies

Year:

2005

Language:

english

File:

PDF, 338 KB

english, 2005

41

Targeting mutant huntingtin for the development of disease-modifying therapy

Thomas Appl, Linda Kaltenbach, Donald C. Lo, Georg C. Terstappen

Journal:

Drug Discovery Today

Year:

2012

Language:

english

File:

PDF, 321 KB

english, 2012

42

A Continuous Time-Resolved Fluorescence Assay for Identification of BACE1 Inhibitors

Porcari, Valentina, Magnoni, Letizia, Terstappen, Georg C., Fecke, Wolfgang

Journal:

Assay and Drug Development Technologies

Year:

2005

Language:

english

File:

PDF, 332 KB

english, 2005

43

P2-462: SEN12333 (WAY-317538), a novel alpha7 nicotinic receptor agonist with neuroprotective efficacy: Implication for neurodegenerative diseases therapy

Scali, Carla, Gianfriddo, Marco, Roncarati, Renza, Dunlop, John, Terstappen, Georg C.

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 71 KB

english, 2008

44

P2-163: Thimet oligopeptidase expression is increased in Alzheimer's disease brain

Hoozemans, Jeroen J.M., van Haastert, Elise S., Hazes, Thierry, Caricasole, Andrea, Pollio, Guiseppe, Terstappen, Georg C., Rozemuller, Annemieke J.M.

Journal:

Alzheimer's & Dementia

Year:

2008

Language:

english

File:

PDF, 59 KB

english, 2008

45

Therapeutic targets for Alzheimer's disease

Tarditi, Alessia, Caricasole, Andrea, Terstappen, Georg

Journal:

Expert Opinion on Therapeutic Targets

Year:

2009

Language:

english

File:

PDF, 460 KB

english, 2009

46

Screening technologies for ion channel drug discovery

Terstappen, Georg C, Roncarati, Renza, Dunlop, John, Peri, Ravikumar

Journal:

Future Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 5.23 MB

english, 2010

47

Molecular cloning and characterization of a novel human variant of RIC-3, a putative chaperone of nicotinic acetylcholine receptors

Seredenina, Tamara, Ferraro, Teresa, Terstappen, Georg C., Caricasole, Andrea, Roncarati, Renza

Journal:

Bioscience Reports

Year:

2008

Language:

english

File:

PDF, 589 KB

english, 2008

48

Label-free detection of small-molecule binding to a GPCR in the membrane environment

Heym, Roland G., Hornberger, Wilfried B., Lakics, Viktor, Terstappen, Georg C.

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2015

Language:

english

File:

PDF, 858 KB

english, 2015

49

Not a dilemma: target deconvolution in drug discovery

Terstappen, Georg C

Journal:

Future Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 912 KB

english, 2009

50

Functional screening of α7 nicotinic receptor ligands

Dunlop, John, Peri, Ravikumar, Terstappen, Georg C, Bowlby, Mark

Journal:

Expert Opinion on Drug Discovery

Year:

2008

Language:

english

File:

PDF, 341 KB

english, 2008

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